WHAT ARE MICRONUTRIENTS?
Micronutrients, as opposed to macronutrients (protein, carbohydrates and fat), are comprised of vitamins and minerals which are required in small quantities to ensure normal metabolism, growth and physical well‐being.
No single food contains all of the vitamins and minerals we need and, therefore, a balanced and varied diet is necessary for an adequate intake of all micronutrients.
These are essential organic nutrients, most of which are not made in the body, or only in insufficient amounts,
and usually must be obtained through food. When dietary intake of a vitamin is inadequate, deficiency disorders result. Although vitamins are only present and required in minute quantities, compared to the macronutrients, they are just as vital to health and need to be considered in the context of nutrition quality.
These are inorganic nutrients that also play a key role in ensuring health and well‐ being. They include the trace elements copper, iodine, iron, manganese, selenium, and zinc together with the macro elements calcium, magnesium, potassium, and sodium. As with vitamins, minerals are found in small quantities within the body and they are obtained from a wide variety of foods.
Micronutrients that are free-floating in your blood and exist outside the cells, determined in serum are called extracellular micronutrients. These extracellular micronutrients are a static measure of what is in your blood at any given time. These are dependent on your short-term intake of supplements or diet and give a direct assessment of your baseline micronutrient levels. Extracellular nutrient tests reflect a person’s diet over a relatively narrow time frame.
Intracellular micronutrients are the micronutrients absorbed by your circulating white blood cells and red blood cells. Cellular micronutrient absorption is an important step in maintaining and promoting optimal functioning of all our cells. It is important to understand that, even though you may be consuming an adequate or healthy diet or supplements, your cellular intake levels of those nutrients may not be sufficient and may still provide risks for deficiencies and the disorders associated with them.
Your genetics, aging, lifestyle, chronic illness, and medications all affect your cellular nutrient absorption. The intracellular portion of Vibrant’s micronutrient test takes all the above factors into consideration to identify your cellular nutrient absorption status. This test can reveal a person’s functional nutritional status over a much longer time (4-6 months) than extracellular testing.
ROLE OF MICRONUTRIENTS
Almost every physiological function in your body requires micronutrients to function optimally. Vitamin, minerals and anti-oxidants play a key role in:
Producing and releasing energy.
Strengthening the immune system.
Reducing systemic inflammation.
Protecting against free radical damage.
Maintaining a healthy hormonal balance (i.e. thyroid, sex hormones, adrenal hormones, neurotransmitters/brain hormones, etc.).
Maintaining insulin sensitivity.
Slowing down cellular aging.
Promoting the health of all tissues: skin, bone, brain, breast, gut, prostate, heart, muscle, organs, etc.
Protecting against the development, progression, and recurrence of cancer.
WHY TEST FOR MICRONUTRIENTS?
THE BENEFITS OF EXTRACELLULAR TESTING INCLUDE:
Identifying baseline nutritional deficiencies.
Detecting higher than normal levels of vitamins and minerals in your blood. Identifying excesses of nutrients caused by uncontrolled supplementation, to prevent the increased risk of certain chronic diseases or nutrient toxicity side effects.
Avoiding unnecessary spending on costly supplements.
Providing a short-term nutritional status of the last few days.
Extracellular micronutrients have been well studied and deficiencies have correlated to multiple chronic diseases including cancer, Alzheimer’s, diabetes, and cardiovascular diseases. 1,2,3,4. Testing extracellular micronutrients also play a role in patient management for such chronic diseases.
THE BENEFITS OF INTRACELLULAR TESTING INCLUDE:
Identifying functional deficiencies in intracellular micronutrient levels (cellular nutrient absorption deficiency).
Identifying essential micronutrient absorption deficiencies which cause or increase the risk of chronic diseases.
Providing a long-term nutritional status of the previous 4-6 months.
Intracellular micronutrients have been studied scientifically and have long been considered a more sensitive tissue measure of micronutrient absorption. For example, vitamin C levels in lymphocytes have been found to be deficient in Type 2 diabetes patients as compared to plasma levels. 5 RBC folate and magnesium are clinically more significant than whole blood measures of these nutrients. 6 RBC omega-3 and omega-6 fatty acid levels have been found to be markers of accelerated structural and cognitive aging. 7
Knowing both your extracellular and intracellular micronutrient levels are key to a thorough understanding of your nutritional requirements at a foundational level, which may contribute to your risk for disease, while simultaneously and positively impacting your overall health and well-being.
VIBRANT MICRONUTRIENTS TEST
The only test that provides a comprehensive extracellular and intracellular assessment of the levels of the most important vitamins, minerals, antioxidants, fatty acids and amino acids.
HOW DO YOU ORDER VIBRANT’S MICRONUTRIENTS TEST?
Vibrant’s micronutrients test is only available to order through your provider.
WHO SHOULD RUN THE VIBRANT MICRONUTRIENTS TEST?
This testing would be most beneficial if you:
Chronic diseases like diabetes, cardiovascular conditions, and/or arthritis.
Numbness/tingling in your hands or feet.
Weakened Immune system.
Digestive issues/disorders like celiac, wheat sensitivity, IBS, IBD, and SIBO
Stress, feeling tired, or chronic fatigue.
Have a history of
Long-term use of prescription medications.
Are Someone who is a
Athletic competitor/exercise regularly.
Vegan or Vegetarian.
Vibrant’s patented technology and reporting allow for high sensitivity quantitative detection of intracellular micronutrients.
Vibrant provides both Extracellular and Intracellular testing for a thorough understanding of your short-term and long term nutritional status and requirements.
High Accuracy and high precision testing enabled by automation and advanced testing methodologies.
Clinically relevant RBC Folate, Omega fatty acids, and Magnesium are measured.
WBC levels are normalized to total WBC count.
Fast TAT of 14 calendar days.
Support team: highly qualiﬁed expert dietitians available to provide support on dietary plans and supplementation for patients.
Advanced reporting with easy to interpret results and repletion suggestions.
Comprehensive back up testing to identify potential sources of malabsorption.
WHAT HAPPENS IN THE LAB?
Three tubes will need to be drawn, one trace element serum tube and two whole blood K2EDTA tubes. The trace element tube will need to be spun down, followed by pipetting the serum into a trace element-free transfer tube.
The transfer tube, with the separated serum, and the whole blood tubes are then sent to the lab for processing.
In the lab, one of the whole blood samples is spun down so that the RBC can be collected from the bottom of tubes.
WBC will be collected from the other whole blood sample through spin-down. Robotic assay stations are utilized to aspirate WBC and ensure accurate extraction with high precision.
All three subsets are processed separately to isolate appropriate micronutrients for injection into mass-spectrometry. All micronutrient levels are measured in an advanced state-of-the-art mass spectrometer that provides increased sensitivity for challenging compounds, enhanced detection system with six orders of linear dynamic range to ensure sensitivity is accessible, and a tool-free probe design that provides improved reproducibility between users.
Nutrients measured in RBCs include: folate, iron, omega-3 and omega-6 fatty acids, and magnesium.
Serum micronutrient measurements provide extracellular levels.
WBC measurements are done and total WBC counts are taken on an automated cell counter. Intracellular WBC levels are normalized to the total WBC count in a patient’s sample. This normalization is a key step in ensuring minimal variability in results due to specimen differences. Because there are no external stimuli provided to stimulate the cells, all variabilities involved in such processes are removed, thereby providing the most accurate and quantitative method available for intracellular testing.
All reports are generated with reference ranges and an easy to interpret educational guide on each of the micronutrients.
WHY NOT SIMPLY TAKE ADDITIONAL MICRONUTRIENT SUPPLEMENTS?
Though it would seem obvious to boost the body’s nutrients with one of the many commercially available supplements, the human body is more complex than that. Plenty of evidence exists to show that micronutrient excess can also cause harm and long-term supplement intake can risk excessive levels.
Certain nutrients perform best in the presence of other nutrients. For example, the body needs vitamin D to absorb calcium.
Certain nutrients may perform counteractive functions. For example, beta-carotene and vitamin C enhance iron absorption, while calcium and polyphenols appear to reduce the absorption of iron. 8
Also, numerous factors can affect proper nutrient absorption:
Potential genetic abnormalities
Tobacco and alcohol use
The type of foods you eat, as well as what they contain
Intestine or stomach resection
Intestinal bacteria imbalance